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It is not known who first discovered the stimulant properties of caffeine, but it was first extracted in 1819 by the German chemist, Friedlieb Ferdinand Runge, who called it kaffebase (coffee base)

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I like more of the fruity stuff, she says of the e-cigarette flavorings that line the walls of the shop

Other methods for quitting like Nicotine Replacement Therapy (NRT) are currently considered more effective

Relative survival is becoming recognised as the most appropriate approach for many cohort studies [25]