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It directly affects the synthesis of glutathione when the dietary content of thiamin-containing amino acids is low

TABLE 1 Characteristics of the negative observational studies regarding the relationship of Klotho with kidney function

Rev Neurol 2003;36:105864.

Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)

The cardiovascular benefits have substantial support, especially for certain clinical populations