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Statistical analysis All statistical analyses were carried out using the metafor package (version 1.99) in the statistical programming language R (version 3.3.1)

developed a PLGA-based nanocarrier for PD therapy, combining pramipexole (PX, a dopamine agonist) with a photothermal agent (Au nanospheres) encapsulated in PLGA nanoparticles (Au-PX-PLGA) 125

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3.2 Non-pharmacological treatments of PDs The non-pharmacological treatments of PDs include various approaches like physical, occupational, speech, and nutritional therapy and exercise (58, 59)

No evidence-based guidelines regarding the use of B 12 testing in people with suspected B 12 deficiency