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Its pathogenesis primarily involves immune dysregulation, including breakdown of immune tolerance, alterations in the immune microenvironment, and dysregulation of T cell subsets (158, 159)

Autophagy biomarkers beclin 1 and p62 are increased in cerebrospinal fluid after traumatic brain injury

With the current absence of technologies to rectify the actual mutations that underlie mitochondrial diseases, medical science can only address the resulting oxidative stress as a potential therapeutic option

The researchers looked at the brain-derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton protein (Arc) as well as cell proliferation using Ki-67 and NeuroD markers

Some enzymes, such as superoxide dismutase, glutathione peroxidase and catalase act in a mutually supporting defense action against ROS (Krishnamurthy and Wadhwani 2012)