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Sorafenib is the only first-line therapeutic in clinical practice for advanced HCC treatment by inducing apoptosis and impeding angiogenesis (Dixon et al., 2014

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Chitosan-based NPs can adhere to mucus membranes, facilitating prolonged and localized drug release, and are widely utilized in wound healing, ocular therapy, periodontal and cardiac repair, and orthopedic tissue regeneration [131]