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With the help of proteomics, oxidative modifications to glycolytic enzymes, ATP synthase, -enolase, aconitase (enzyme containing iron-sulfur core), creatine kinase (maintains ATP levels in neurons), and other enzymes have been identified (Butterfield and Boyd-Kimball 2018)

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Missed-dose rules are straightforward: if the next scheduled dose is near, skip the missed one rather than doubling up