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Acetylcysteine (Fluimucil) granules and tablets are contraindicated in patients suffering from phenylketonuria due to the aspartame content

This observation, coupled with the added stability contributed by C-terminal amidation and the desire to increase the hydrophobicity of the peptide, led to the generation of a series of compounds with the structure N -acyl-Tyr-Ile-(6) amino-hexanoic amide

J-W L, Geng H, Chen Z, Klemm L, Cosgun KN, Xiao G, Masouleh B, Hurtz C, Parekh S, Kornblau SM , Melnick A, Abbas A, Paietta E, Mschen M

doi:10.1002/aur.1691 101. Robertson, C