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Copper serves as a key enzymatic cofactor for pathways involved in collagen and elastin maturation (cross-linking) , antioxidant defense , and broader tissue remodeling

Some formulations may require refrigeration

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Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease