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The other pharmacological approaches for targeting 7nAChR include drugs promising to have therapeutic effects through 7nAChR, which are not essential to be agonists

Thus pre-treatment with L-arginine counteracted the antidepressant-like effect of imipramine, venlafaxine and bupropion (Krass et al., 2011), while inhibition of nitric oxide levels within the hippocampus can induce antidepressant like effects (Joca and Guimaracs, 2006)

Thus, depletion of nuclear, but not cytoplasmic glutathione levels is able to decrease Id-2 expression, impairing cell growth

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Hepcidin, a liver-derived antimicrobial peptide, negatively regulates FPN1, leading to tissue iron overload and promoting ferroptosis, underscoring its crucial role in iron metabolism regulation