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Eric Verdin, in a review published in Science (2015), documented NAD+ depletion across aging tissues and its downstream effects on sirtuin enzyme activity, PARP-mediated DNA repair, and mitochondrial function

Front Neurosci 12:214 Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Forster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Treatment by folates and betaine combined with a low-methionine diet is effective in vitamin B 6 nonresponders (Franken et al, 1994)

"How have your muscles and tendons felt?" Robertson asked

Effects of oral vitamin E on treatment of atopic dermatitis: a randomized controlled trial