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Enteroviral 2B protein has been shown to interact with mitochondrial voltage-dependent anion channel 3 (VDAC3) to induce ROS production, and knockdown of VDAC3 significantly reduces EV71-induced mtROS generation and viral replication 132

In order to maximize effectiveness, it should be taken with food

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Whether that weight rests on independent scientific assessment or on a committee reconstituted to deliver a preferred political outcome is the question that will shape how much weight it deserves

Frontiers in Nutrition, 2022