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Introduction Angiotensin IV (Ang IV) is a small bioactive peptide in the renin-angiotensin system (RAS) formed after proteolytic degradation of angiotensin II (Ang II)

In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

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