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When oxidation occurs, the free radicals released into the bloodstream can lead to chain reactions where cells are damaged

Notably, genes involved in the TSS pathway, cystine uptake and glutathione recycling (such as CBS, CSE, SLC7A11 and GSR) were DNA hypomethylated after DMF treatment 30 , supporting a regulatory effect of DMF on these pathways

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Rather than suppressing the entire immune response, these peptides can potentially shift the balance between pro-inflammatory and anti-inflammatory processes, promote regulatory T cell function, and restore tolerance mechanisms that have broken down in lupus

In fact, another study conducted on 77 patients for 1 day showed no difference between patients treated with vitamin D 2000 IU and placebo (31)