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See Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase, A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems, and Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways for further information

Supplemental Figure 9

BPC-157s true therapeutic power lies in its ability to simultaneously act at both ends of this axis, creating a synergistic effect where peripheral healing directly translates to central nervous system stability

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It seems, that just like AT II-blockade, aldosterone-antagonists may mitigate RN, although aldosterone itself is not upregulated