2.1 Candida Candida species are major fungal pathogens, particularly in immunocompromised individuals, where infections are associated with high mortality, up to 45% despite antifungal therapy (Robbins and Cowen, 2025)
Examples: manual muscle testing grades by major muscle groups transfer ability (sit-to-stand, bed-to-chair) gait observations and balance findings functional test results (timed sit-to-stand, walking tolerance, assistive device use) Step 3: Prove functional impact Link weakness to daily life: bathing, dressing, toileting meal prep, household mobility fall risk and safety concerns work limitations when relevant Step 4: Exclude focal and neurologic patterns Document why this is generalized rather than focal: no unilateral deficit pattern no dermatomal-only weakness pattern
This reaction converts the reduced form of glutathione (GSH) into oxidized glutathione (GSSG), which is then reduced back to GSH by glutathione reductase (GR), using electrons from NADPH (Vairetti et al., 2021)
Pickart & Margolina's 2018 review reported modulation of approximately 4,000 human genes in cultured cells [16]
However, in SD, as mentioned above, there is an increased, deregulated, activation of these cells, which leads to an increased production of ROS, impossible to control only through the endogenous amount of antioxidants
