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The reaction is elegantly simple: 2GSH+H2O2GPxGSSG+2H2O2GSH+H2O2GPxGSSG+2H2 Two molecules of reduced glutathione (GSH) donate electrons to neutralize one molecule of hydrogen peroxide, producing water and oxidized glutathione (GSSG)

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Sakkas D., Mariethoz E., Manicardi G., Bizzaro D., Bianchi P., Bianchi U

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Furthermore, it has been seen that a combination of CoQ10 and ALA is superior to monotherapy in treating oxidative nephrotoxicity induced by cisplatin [137]