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Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

2009 Sep;42(13-14):1431-7

In these circumstances, using methylfolate or folinic acid may be a more appropriate strategy than simply increasing folic acid intake

4e) and higher accumulation of mitochondrial mass, probably due to prevention of ROS-induced organellar damage (Fig

Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Davinelli et al., 2025) In ASD children, the oxidative stress is not only higher, but it manifests in a complicated new pattern concerning different types of ROS and antioxidants (Hirayama et al., 2020)