In the same context, it is believed that the production of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 are also thought to contribute to the intestinal damage caused by MTX
The zonulin-induced disruption of the tight junction complex allows paracellular transport of gliadin and the eventual uptake of gliadin into systemic circulation, thereby causing the inflammatory response exhibited by patients with celiac disease (26, 34, 35)
and A.W
In addition to the induction of synergistic cytotoxic effects through interference in tumor growth and survival signaling, combination treatment with TQ also exhibited chemo-protective effects and limited organ toxicity (Brown et al., 2014)
Repair articular cartilage and improve osteoarthritis (cartilage bone linkage protection) Promote intestinal calcium absorption Calcium transporters: upregulate the expression of intestinal calcium transporters (TRPV6, Calbindin-D9k) by 30% -40%, and increase intestinal calcium absorption rate by 25% -35%
