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There is very small risk of forming ulcers in the sleeve and developing a narrowed sleeve (stenosis) that causes blockage.

Clin Sci 91 : 7986

The Cellular Problem in Chronic Injury: The Tissue Never Gets the Right Message A useful way to think about chronic injury is that the tissue is trapped between two competing signals: repair and protect. When a tissue has been repeatedly stressed, it often behaves as if it is still under threat

Despite these constraints, several practical translational anchors are already available

Clinical and molecular characterization of 6 children with glutamate-cysteine ligase deficiency causing hemolytic anemia