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The therapeutic effect relies on consistent dosing to maintain elevated intracellular GSH concentrations over time

To dissect the biochemical derangements imposed by chronic hyperglycaemia, a three-dimensional, tissue-engineered wound model has been engineered that faithfully recapitulates the accumulation of AGEs and the attendant impairment of fibroblast proliferation, angiogenic signaling, and extracellular-matrix turnover that underlie the stalled diabetic repair program (129)

Mitochondrial dysfunction is another critical aspect of AD pathogenesis linked to oxidative stress

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It's often used to treat androgenetic alopecia (male or female pattern baldness)