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S-adenosylmethionine acts as a universal methyl donor for several reactions, being the major biological methylating agent ( Before producing methylation potential, Met may also play an indirect role in polyamine (putrescine, spermidine, and spermine) synthesis ( Figure 1 )

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The resulting systems were prepared for simulations using in-house scripts based on HTMD2.3.2 45 and VMD1.9.4 frameworks